Methodologies are being tested using the database to more validly determine beneficial and adverse drug effects. Statistical modeling includes multivariable regression models, propensity scores, sensitivity analyses. Design methodologies include crossover studies (e.g. between sibling-within mother designs in pregnancy), prescription symmetry analyses and instrumental variable analyses.


Pouwels KB, Widyakusuma NN, Bos JH, Hak E.
Association between statins and infections among patients with diabetes: a cohort and prescription sequence symmetry analysis.
Pharmacoepidemiol Drug Saf. 2016